Peter Benjamin Parker is high school student living in Queens, NYC, who acquired superhuman abilities after receiving a bite from an experimental spider during a school field trip, eventually operating in New York City as the friendly neighborhood Spider-Man. Publicly, he worked as a photographer for the Daily Bugle, and gained notoriety for capturing photos of his alter ego fighting crime in New York City. Spider-Man fought multiple villains throughout his career as the web-slinging vigilante, including Green Goblin, Doctor Octopus, Sandman, Venom, Vulture and the Lizard. Eventually, after breaking up with Mary Jane Watson, Parker started a relationship with cat burgler Felicia Hardy.
Later, after being summoned to a parallel reality due to Doctor Strange's corrupted spell, Parker met that reality's Spider-Man, along with another alternate-reality Spider-Man. After learning that Green Goblin, Doctor Octopus, and Sandman had also crossed universes, Parker engineered an anti-serum for Green Goblin for use in a subsequent battle on the Statue of Liberty. The three Spider-Men, and Octavius, fought against Green Goblin, Sandman, Electro, and Lizard to cure their afflictions. When the Spider-Man from Strange's universe attempted to kill Green Goblin for murdering his aunt May Parker, Spider-Man compelled him to stand down. After all of their adversaries had been cured, Spider-Man embraced his alternate selves before being returned to his home universe by Strange.